Endocrine Abstracts

Introduction: Hypopituitarism is the most frequent side effect of radiation or gamma knife radiosurgery (GKRS) for sellar diseases. There is a paucity of literature on the impact of GKRS on the hormonal profile of non-sellar diseases, even though the impact of radiation on pituitary hormones has been widely explored in sellar as well as non-sellar pathologies. In patients receiving treatment for non-sellar diseases, we assessed the effect of GKRS on hormonal p...

Background: There is no effective medical treatment available for non-functioning pituitary neuroendocrine tumours (NF-PitNETs). Recurrence (7-12%) or incomplete resection (30-45%) is a common feature. Thus, finding novel medical therapies to help the management of these tumours would be of great value. By using high-throughput mass spectrometry combined with functional characterisation, we explored novel therapeutic targets for NF-PitNETs.<p class="abstex...